Unique aspects of multisystem inflammatory syndrome in children (MIS-C), an uncommon but potentially fatal complication of Covid in children, have been uncovered by a team of researchers in New York, suggesting how the condition begins.
The findings, which were published in the Journal of Allergy and Clinical Immunology, could lead to more accurate MIS-C diagnosis and therapy. "One of the key unresolved concerns concerning MIS-C is how the disease proceeds immunologically from the initial viral event to the final immune-mediated assault," said Mark Gorelik, an assistant professor of paediatrics at Columbia University's Vagelos College of Physicians and Surgeons.
By examining the diversity of immune cells and responses in blood samples collected at the very first encounter with care at the emergency room, before therapies were began, the team compared eight MIS-C patients with 14 patients who had different febrile diseases.
The researchers believe that the altered immune cells discovered in MIS-C patients compared to other individuals may hold a hint to what causes the disease.
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