Former beauty queen Dias was disclosed by Suresh Natrajan by chance when she walked onto his set and was immediately hired for the movement he was shooting. At the age of 21, she won a talent hunt TV show, which gave her a chance to host a Channel V show. She then became the host of Get Gorgeous, a supermodel hunt TV show on the network. Dias featured in the Aussies music video for Australian rock group tittle "Never Let You Go" from their album known as Switch. She afterwards won the title of Femina Miss India World 2007 and represented the country at Miss World 2007 but did not place.The next year Dias participated in Femina Miss India 2007.

Sarah-Jane Dias also scored her maiden major film role in the 2010 Tamil romantic comedy, she was also Theeradha Vilaiyattu Pillai opposite Kollywood star Vishal Krishna. She appeared in a Telugu film named Panjaa with Tollywood star Pawan Kalyan which was released in 2011. She also appeared in the Hindi movies ‘Kyaa Super Kool Hai Hum’ opposite Ritesh Deshmukh in 2012 and in O Teri opposite Pulkit Samrat in 2014. In 2016, she appeared in a Musical Thriller Film Zubaan, which was released in March 2016. She was currently seen in The British-Indian historical film Viceroy's House.