Researchers have recognized the biological mechanism that gives details why some people feel abdominal pain when they eat certain foods.

According to the researchers, up to 20 percent of the world's population suffers from the irritable bowel syndrome (IBS), which causes stomach pain or severe discomfort after eating. The researchers disclosed a mechanism that connects certain foods with activation of the cells that release histamine (called mast cells), and subsequent pain and discomfort.

“With these new insights, we provide further evidence that we are dealing with a real disease,” said researcher Guy Boeckxstaens, Professor at Katholieke Universiteit Leuven in Belgium. In a healthy intestine, the immune system does not react to foods, so the first step was to find out what might cause this tolerance to break down, according to the study published in the journal Nature.

 Since people with IBS often report that their symptoms began after a gastrointestinal infection, such as food poisoning, the researchers started with the idea that an infection, while a particular food is present in the gut, might sensitize the immune system to that food. They infected mice with a stomach bug, and at the same time fed the movalbumin, a protein found in egg white that is commonly used in experiments as a model food antigen.  An antigen is any molecule that provokes an immune response. Once the infection cleared, the mice were given ovalbumin again, to see if their immune systems had become sensitized to it.

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