Oral cancer could soon be diagnosed without the patient having to go through the pain of a biopsy. King George's Medical University (KGMU) researchers have taken a step in the right direction.

The multi-disciplinary research unit (DHR-MRU) of the Department of Health Research Organization, which is based at KGMU, has found promising results in a pilot study that found biomarkers in people's blood and saliva that can diagnose oral cancer. Biomarkers in the blood to diagnose cancer and the role of Vitamin A and its products in cancer treatment and eradication were the subjects of two research investigations.

Prof. Divya Mehrotra of the department of oral and maxillofacial surgery explained: "The biomarkers BCL2 and HSP 70 are the focus of the first investigation. The study included 300 cancer and pre-cancerous individuals. Because the blood samples from the two groups were combined, we came to the conclusion that these biomarkers can be used to diagnose cancer. This will lessen the frequency with which a biopsy is required." The second trial, which involved 250 oral cancer patients, focused on Vitamin A.

"We looked at the role of Vitamin A and related markers in these individuals and discovered that if the enzyme that breaks down Vitamin A isn't working properly, these people are more likely to develop oral cancer. Antioxidant supplements are similarly ineffective in the therapy of such patients "she said.

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