Presence of a Delta-like SARS-CoV-2 mutation exacerbate pandemic's severity
Presence of a Delta-like SARS-CoV-2 mutation exacerbate pandemic's severity
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According to a new study conducted in New York, a SARS-CoV-2 variant with properties similar to the Delta variant could trigger a more severe pandemic with more infections and breakthrough infections/reinfections than variants with either trait alone. The study, which was published in the journal Cell, a variation with increased transmissibility alone would be more harmful than one that could partially elude the immune system. However, a variant with both traits is more likely to induce infections, reinfections, and breakthrough infections than a variant with only one attribute.

"Immune escape - the capacity of a variation to evade the immune system and induce reinfections or breakthrough infections - has been a warning flag so far," said Harvard University researcher Mary Bushman.  "Our data suggest that it's more of a red flag; on its own, it's not such a significant concern. However, when combined with increased transmissibility, it can be a huge concern "Bushman continued. The Delta variant has increased transmissibility and the ability to infect those who have already been infected or vaccinated.

The study simulated a SARS-CoV-2 pandemic with a variety of hypothetical variants, including enhanced transmissibility, like the Alpha variant; partial immune escape, like the Beta variant; enhanced transmissibility with partial immune escape, like the Delta variant; and a variant with neither trait.

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