Breast cancer is one of the fatal diseases and many women are suffering from it. The Researchers have identified a protein that is strongly associated with metastatic breast cancer and that could be a target for future therapies. Metastatic breast cancer is cancer that has spread to other sites in the body, and the vast majority of breast cancer deaths occur in patients in whom cancer has metastasised.
According to the findingsof Journal of Clinical Investigation says that high levels of the protein ZMYND8 could be correlated with poor survival in breast cancer patients.
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According to research, the breast cancer cells that are more aggressive in an oxygen-deprived, or hypoxic, environment. A protein family called hypoxia-inducible factor (HIF) controls responses to hypoxia, switching on pathways that lead to cancer cell growth and spread.
Weibo Luo, Assistant Professor at University of Texas Southwestern Medical Center in the US said, "Our research shows that ZMYND8 is a regulator that activates hundreds of HIF-dependent oncogenes in breast cancer cells.
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Research with a mouse model of breast cancer showed that depletion of the protein blocks the growth of new blood vessels in tumours and leads to breast cancer cell death. Luo further said, This work reveals a possible molecular target for diagnosis and treatment of aggressive disease.