AstraZeneca said on Tuesday it has agreed to supply up to half a million additional doses of its experimental antibody-based COVID-19 combination treatment to the United States for USD205 million.

In October, the Anglo-Swedish drugmaker and U.S. government agencies had initially agreed for a supply of 200,000 doses. The extension brings potential U.S. supplies of the treatment to 700,000 doses and the total value of the deal to USD726 million.

The treatment, AZD7442, is a combination of two monoclonal antibodies and has not been approved for use as yet, AstraZeneca said, adding that the new agreement is contingent on approval by the U.S. Food and Drug Administration. The company said it does not expect any changes to its 2021 forecasts because of the deal.

Meanwhile, in separate news, Germany, Italy and France all paused rollouts on Monday and were later joined by Spain, Portugal, Slovenia and Latvia on Monday over blood clot fears, as the World Health Organization and Europe's medicines watchdog insisted it was safe to use.

But the WHO insisted countries should keep using the vaccine, adding that it had scheduled a meeting of its experts on Tuesday to discuss the vaccine's safety.

Japan considers whether to end Tokyo's COVID-19 emergency

Covid-19 pandemic: European tourism cut in two in 2020

Is AstraZeneca vaccine a reason for blood clots or just a rumor?