Washington: Insulin decreases dopamine levels in the striatum, a brain area that affects reward processing and cognitive functioning, among other things. This connection may play a role in the brain's glucose metabolism and eating behaviour regulation.

Researchers from the German Center for Diabetes Research (DZD) in Tubingen recently published a study in the 'Journal of Clinical Endocrinology & Metabolism' showing that the hormone insulin operates on the most essential neurotransmitter for the reward system, dopamine, in the human brain.

Obesity and Type 2 diabetes are becoming increasingly common worldwide. According to studies, the brain plays a significant role in the development of various diseases. The reward system's most essential neurotransmitter is dopamine. Insulin is a hormone that regulates metabolism in the human body and is released after a meal (homeostatic system). It's unclear how these two systems will interact.

Changes in these systems, on the other hand, have been related to obesity and diabetes. Researchers from the Helmholtz Zentrum Munchen's Institute of Diabetes Research and Metabolic Diseases (IDM) at the University of Tubingen, a partner of the DZD, and Tubingen University Hospital (Innere IV, Director: Professor Andreas Birkenfeld) investigated how the two systems interact in the striatum, the brain's reward centre.

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