New Delhi: India has given the green signal to use the world's first DNA vaccine. In fact, Ahmedabad-based Zydus Cadila has developed a DNA vaccine to fight against corona. With this vaccine, India has become the first country in the world to have a DNA-based vaccine to prevent the epidemic. Some scientists now say that DNA vaccines are better than other vaccines, as they are easier to store. On the other hand, some scientists believe that this technique can also be used for other diseases like dengue.

Dr Ishwaran Srikumar, senior scientist at the Rajiv Gandhi Centre for Biotechnology-Thiruvananthapuram, and one of the authors concerned with peer-review so far said, 'We know that the virus has four serotypes, but we found that the serotypes contained genetic variations. Any sequence is considered a different genotype when it differs more than 6 per cent. The team then developed a conscious sequence that was the same in all genotypes.' Researchers resorted to indexing viruses from four regions of the country that report dengue cases.

The virus that causes dengue has four different viral antigens – essentially proteins that cause infection and against which antibodies are prepared. Scientists selected a part called EDIII (envelope protein smaller for domain III) from all four serotypes of the virus, widely considered the most important viral protein. At the same time, scientists also selected NS1 protein from the DENV2 serotype, which causes severe dengue with internal bleeding and a drop in blood pressure.

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