Bhopal: IISER Scientists announces invention of technology for Protein Engg

Jun 07 2021 07:36 PM
Bhopal: IISER Scientists announces invention of technology for Protein Engg

Bhopal: Researchers at the Indian Institute of Science Education and Research (IISER) Bhopal announced on Monday, the launch of their new technology invention for protein engineering, that they have named Linchpin Directed Modification (LDM) platform.

 According to the researchers, the technology can deliver active molecules to specific sections of proteins and hence, can help get rid of the tumours without harming the patient's healthy cells.

Vishal Rai, Associate Professor, Department of Chemistry, IISER Bhopal said,  "Successful platforms for precision engineering of proteins depend on the core understanding of molecular and social behaviour of proteins in the chemical reactions. Protein modifications typically involve attaching specific chemicals to strategic sections of the proteins. Such protein modifications are commonly seen in nature, but the intricate machinery is challenging to replicate in the lab,"

 "The difficulty in attaching specific tags, markers, and therapeutic molecules to specific protein regions arises from the complexity of the protein structure and the non-specific nature of many of the modifiers," Rai added.

The LDM platform is empowered by reagents made of three key components. A key advantage of the LDM platform is that it does not modify the structure or functions of the native protein, he said. The LDM reagents can precisely label biologically active molecules such as antibodies that can be delivered accurately at the designated cells. The research team has shown that the LDM molecule successfully delivers homogeneous conjugate of a monoclonal antibody and drug for selective inhibition of breast cancer cells.


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