New York: Despite poor antibody responses, T-cell responses against the variant are nevertheless robust in most persons with past SARS-CoV-2 infection or immunisation, according to a study. According to researchers at Massachusetts General Hospital, this also protects against severe disease (MGH).

When a person is infected with the Covid-19-causing virus SARS-CoV-2, the immune system responds by producing antibodies and T cells that target viral proteins and help the person clear the infection.

Even in persons who have been vaccinated against Covid-19, it has become established that the latest Omicron variant of SARS-CoV-2 can elude antibody responses. T cell responses against the Omicron spike protein were mainly sustained in persons with prior infection, vaccination, both prior infection and vaccination, and booster inoculation, according to new research published in the journal Cell.

Individuals who had previously been infected developed antibodies to the virus's other proteins. The researchers took blood samples from 76 persons, both vaccinated and unvaccinated, who had previously been infected with SARS-CoV-2.

"Even when antibodies failed to recognise Omicron, T cells from most people retained their recognition. This is excellent news "Anusha Nathan, a medical student at the Ragon Institute of MGH, MIT, and Harvard, claimed she was a co-lead author.

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